latest news on glp 1 GLP-1 drugs promise wider health benefits, but experts urge caution use New warning issued over compounded

Intracellular glutathione assay Total intracellular GSH from tissues or cells (10 cm dishes) were assayed using the Cayman Chemicals Glutathione Kit as per the manufacturer's instructions

However, emerging evidence suggests that GLP-1RAs could be beneficial for specific eating disorder symptoms in individuals with obesity who do not have diabetes, potentially reducing binge eating, dietary disinhibition, overall eating disorder psychopathology, and concerns about body shape (Chao et al., 2019)

The second part of the strategy was to find the optimal combination of a fatty acid with high albumin affinity, attached to GLP-1 via a water compatible chemical linker, to ensure that the derivatized peptide had high GLP-1R potency in the presence of albumin

doi: 10.1002/rcm.1887

Phase 2 data showed weight loss around 24% at 48 weeks, but retatrutide is still earlier in development